Temazolamide in breast cancer with brain metastasis watch online
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Patupilone, another BBB-permeable epothilone, has also demonstrated CNS activity in breast cancer, and future trials are under consideration [ 32 ]. Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse: Although a dose-dense 2 weekly regimen was evaluated, protracted temozolomide schedules such as continuous day administration may be more successful at depleting MGMT activity, even at relatively low daily doses [ 17 ]. Differential radiosensitizing potential of temozolomide in MGMT promoter methylated glioblastoma multiforme cell lines. J Cancer Res Clin Oncol The expected response in this group of patients might be small and the activity of temozolomide could therefore have been missed.
The incidence of brain metastases is increasing, possibly because of several factors: (1) an aging population, (2) improved imaging studies, and (3) longer survival of patients with cancer because of improved systemic therapies.1 The primary tumor types most likely to metastasize to the brain are lung cancer (25% to 30%), breast cancer (10%. T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Apr 18, · With respect to breast cancer brain metastases, capecitabine has been evaluated in a phase I study in combination with temozolomide, with a reported response rate of 18%. CNS activity has also been reported in a case series from Memorial Sloan-Kettering Cancer Center, with capecitabine given as a single agent [ 25 ].
Brain metastases from solid tumours are associated with poor prognosis despite aggressive treatment. Temozolomide can be used for the treatment of glioblastoma multiforme as well as melanoma. It has also been shown to have activity in patients with brain metastases from various malignancies, since it can cross the blood-brain barrier. To better understand the efficacy of temozolomide in the treatment of brain metastases, we carried out a temazolamide in breast cancer with brain metastasis of 21 published clinical trials to determine whether temozolomide would benefit patients with brain metastases from solid tumours. Information regarding complete response, partial response, stable disease, objective response and objective response rate were collected to assess clinical outcomes.
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